Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 8/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | KYNU | Q16719 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL269404 | 0.83 | KYNU (0.62) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL187849 | 0.83 | KYNU (0.62) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL29678939 | 0.83 | KYNU (0.62) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL711351 | 0.79 | GAA (0.52) | POLBKMT2ACYP1A2GAAALDH1A1 | |
| SCHEMBL19410220 | 0.79 | KYNU (0.57) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL5709042 | 0.77 | MAPT (0.63) | POLBMEN1KMT2ACYP1A2CNR2 | |
| SCHEMBL11216442 | 0.77 | MAPT (0.63) | POLBMEN1KMT2ACYP1A2CNR2 | |
| SCHEMBL535707 | 0.76 | KYNU (0.57) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL13435790 | 0.76 | KYNU (0.57) | ALDH1A1PLAUELANEKYNU | |
| SCHEMBL6179815 | 0.75 | MAPK1 (0.50) | MEN1KMT2AMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |
| US-5420155-A | Treatment of nervous system disorders with derivatives of 4-hydroxy-2-(1H)-pyrrolones such as strokes, antiischemic agents or cardiovascular disorders | MERCK SHARP & DOHME LTD. (GB) | 1995-05-30 | — | — | US | disclosed |