Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4688953 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4692406 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4687303 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4692407 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4687309 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4688198 | 0.79 | MAPT (0.55) | SMN1; SMN2KDM4ERAB9AL3MBTL1MAPT | |
| SCHEMBL4688204 | 0.79 | MAPT (0.55) | SMN1; SMN2KDM4ERAB9AL3MBTL1MAPT | |
| SCHEMBL4690923 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2KDM4EL3MBTL1HPGDKMT2A | |
| SCHEMBL4744070 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 | |
| SCHEMBL4744066 | 0.77 | ALDH1A1 (0.43) | SMN1; SMN2KDM4ENPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |