Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 17/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CCL5 | P13501 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692016 | 0.82 | CCR5 (0.40) | CCR5SLC6A9 | |
| SCHEMBL4694443 | 0.82 | CCR5 (0.55) | CCR5SLC6A9KCNH2 | |
| SCHEMBL4691770 | 0.81 | CCR5 (0.62) | CCR5CCL5 | |
| SCHEMBL4691781 | 0.81 | CCR5 (0.62) | CCR5CCL5 | |
| SCHEMBL4691775 | 0.81 | CCR5 (0.62) | CCR5CCL5 | |
| SCHEMBL4690751 | 0.80 | CCR5 (0.53) | CCR5SLC6A9 | |
| SCHEMBL4694351 | 0.79 | CCR5 (0.52) | CCR5SLC6A9 | |
| SCHEMBL4689957 | 0.79 | CCR5 (0.52) | CCR5SLC6A9 | |
| SCHEMBL4695355 | 0.77 | CCR5 (0.56) | CCR5SLC6A9 | |
| SCHEMBL4694278 | 0.77 | CCR5 (0.48) | CCR5SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |