Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | GRM4 | Q14833 | 7/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692406 | 1.00 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4687303 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4687309 | 0.90 | SMN1; SMN2 (0.57) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4688953 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4688958 | 0.82 | SMN1; SMN2 (0.49) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4692202 | 0.81 | KDM4E (0.60) | SMN1; SMN2KDM4EMAPTGAASNCA | |
| SCHEMBL4692207 | 0.81 | KDM4E (0.60) | SMN1; SMN2KDM4EMAPTGAASNCA | |
| SCHEMBL4688681 | 0.81 | LMNA (0.54) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL4688679 | 0.81 | LMNA (0.54) | SMN1; SMN2RAB9ANPC1KDM4EMAPT | |
| SCHEMBL27533555 | 0.79 | KDM4E (0.54) | RAB9ANPC1KDM4EMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581496-A4 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES INC (US) | 2008-04-23 | — | — | EP | disclosed |
| EP-1581496-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004050613-A2 | 2-SUBSTITUTED-3-PROPENAMIDE DERIVATIVES AND METHODS OF USING THE SAME | GILEAD SCIENCES, INC. (US) | 2004-06-17 | — | — | WO | disclosed |