Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 15/20 | 0.53 |
| ▸ | GAA | P10253 | 15/20 | 0.53 |
| ▸ | SI | P14410 | 15/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 15/20 | 0.53 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CBFB | Q13951 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1170892 | 0.79 | MGAM (0.71) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL353891 | 0.79 | PARP1 (0.56) | MGAMGAASIMGAM2ESR1 | |
| Bromide SCHEMBL5318091 | 0.78 | PARP1 (0.55) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL3109602 | 0.76 | MGAM (0.60) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL3424862 | 0.76 | MGAM (0.60) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL17801881 | 0.76 | MGAM (0.53) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL727228 | 0.76 | MGAM (0.53) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL8956250 | 0.76 | PSMD14 (0.39) | MGAMGAASIMGAM2TDP1 | |
| SCHEMBL6139625 | 0.76 | MGAM (0.60) | MGAMGAASIMGAM2ESR1 | |
| SCHEMBL110724 | 0.76 | MGAM (0.53) | MGAMGAASIMGAM2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879896-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006107784-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2006-10-12 | — | — | WO | disclosed |