Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 15/20 | 0.63 |
| ▸ | AXL | P30530 | 8/20 | 0.63 |
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | MERTK | Q12866 | 4/20 | 0.60 |
| ▸ | RET | P07949 | 3/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 3/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL469398 | 0.93 | MET (0.73) | METAXLKDRMERTKRET | |
| SCHEMBL469351 | 0.92 | MET (0.63) | METAXLKDRMERTKRET | |
| SCHEMBL469390 | 0.91 | MET (0.62) | METAXLKDRMERTKRET | |
| SCHEMBL469288 | 0.91 | MET (0.62) | METAXLKDRMERTKRET | |
| SCHEMBL469285 | 0.91 | MET (0.61) | METAXLKDRMERTKRET | |
| SCHEMBL469276 | 0.88 | MET (0.65) | METAXLKDRMERTKRET | |
| Vilzemetkib SCHEMBL469353 | 0.86 | MET (0.76) | METAXLKDRMERTKRET | |
| SCHEMBL469345 | 0.85 | MET (0.75) | METAXLKDRMERTKRET | |
| SCHEMBL5045440 | 0.84 | MET (0.73) | METAXLKDRMERTKRET | |
| SCHEMBL469286 | 0.84 | MET (0.72) | METAXLKDRMERTKRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |