SCHEMBL469351 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MET	P08581	15/20	0.63

▸	KDR	P35968	8/20	0.63

▸	AXL	P30530	8/20	0.63

▸	MERTK	Q12866	4/20	0.60

▸	RET	P07949	3/20	0.59

▸	KIT	P10721	3/20	0.59

▸	FLT3	P36888	3/20	0.59

▸	PDGFRB	P09619	2/20	0.59

▸	AURKA	O14965	2/20	0.59

▸	RIPK2	O43353	2/20	0.59

▸	ABL1	P00519	2/20	0.59

▸	EGFR	P00533	2/20	0.59

▸	ERBB2	P04626	2/20	0.59

▸	NTRK1	P04629	2/20	0.59

▸	LCK	P06239	2/20	0.59

▸	LYN	P07948	2/20	0.59

▸	HCK	P08631	2/20	0.59

▸	ADRA2A	P08913	2/20	0.59

▸	BCR	P11274	2/20	0.59

▸	FGFR1	P11362	2/20	0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL5045440	0.93	MET (0.73)	METKDRAXLMERTKRET
SCHEMBL469282	0.92	MET (0.63)	METKDRAXLMERTKRET
SCHEMBL469390	0.91	MET (0.62)	METKDRAXLMERTKRET
SCHEMBL469288	0.91	MET (0.62)	METKDRAXLMERTKRET
SCHEMBL469285	0.91	MET (0.61)	METKDRAXLMERTKRET
SCHEMBL469256	0.88	MET (0.65)	METKDRAXLMERTKRET
SCHEMBL469295	0.88	MET (0.69)	METKDRAXLMERTKRET
SCHEMBL21942119	0.87	MET (0.65)	METKDRAXLMERTKRET
SCHEMBL469350	0.86	AURKB (0.49)	METKDRAXLMERTKRET
Vilzemetkib SCHEMBL469353	0.86	MET (0.76)	METKDRAXLMERTKRET

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2012034055-A2	COMPOUNDS AS C-MET KINASE INHIBITORS	ADVENCHEN LABORATORIES, LLC (US)	2012-03-15	—	—	WO	disclosed