Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171139 | 0.87 | LTA4H (0.65) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4694031 | 0.83 | LTA4H (0.66) | LTA4HKCNH2 | |
| SCHEMBL4966528 | 0.81 | LTA4H (0.60) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2169583 | 0.78 | LTA4H (0.84) | LTA4HKCNH2 | |
| SCHEMBL2168079 | 0.78 | LTA4H (0.98) | LTA4HKCNH2 | |
| SCHEMBL2169317 | 0.77 | LTA4H (0.76) | LTA4HKCNH2 | |
| SCHEMBL2168436 | 0.77 | LTA4H (0.69) | LTA4HKCNH2 | |
| SCHEMBL2168422 | 0.77 | LTA4H (0.69) | LTA4HKCNH2 | |
| SCHEMBL2168164 | 0.77 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL2168381 | 0.77 | LTA4H (1.00) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | claimed |