Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 19/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2171139 | 0.84 | LTA4H (0.65) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4692870 | 0.81 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2168436 | 0.80 | LTA4H (0.69) | LTA4HKCNH2 | |
| SCHEMBL2168422 | 0.80 | LTA4H (0.69) | LTA4HKCNH2 | |
| SCHEMBL22209141 | 0.79 | LTA4H (0.69) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2169583 | 0.79 | LTA4H (0.84) | LTA4HKCNH2 | |
| SCHEMBL2170245 | 0.78 | LTA4H (0.67) | LTA4HKCNH2 | |
| SCHEMBL2181683 | 0.77 | LTA4H (0.55) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2168298 | 0.77 | LTA4H (0.55) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2168778 | 0.77 | LTA4H (0.55) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008100564-A1 | LTA4H MODULATORS AND USES THEROF | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |