Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 15/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 14/20 | 0.36 |
| ▸ | SCD | O00767 | 2/20 | 0.33 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694116 | 0.81 | HCRTR2 (0.38) | HCRTR2HCRTR1 | |
| SCHEMBL4691798 | 0.80 | HCRTR1 (0.42) | HCRTR2HCRTR1 | |
| SCHEMBL4691643 | 0.78 | LMNA (0.43) | KDM4EALDH1A1HCRTR2HCRTR1 | |
| SCHEMBL4695411 | 0.78 | CHRNA4 (0.40) | ALDH1A1HCRTR2HCRTR1 | |
| SCHEMBL4694094 | 0.78 | CHRNB2 (0.44) | ALDH1A1 | |
| SCHEMBL4691191 | 0.77 | HCRTR1 (0.40) | HCRTR2HCRTR1 | |
| SCHEMBL4691531 | 0.77 | HCRTR1 (0.41) | HCRTR2HCRTR1 | |
| SCHEMBL4692504 | 0.77 | HCRTR1 (0.44) | KDM4EALDH1A1HCRTR2HCRTR1 | |
| SCHEMBL4690347 | 0.77 | HCRTR2 (0.42) | HCRTR2HCRTR1 | |
| SCHEMBL4693281 | 0.77 | CHRNB2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |