Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693369 | 0.82 | FFAR1 (0.49) | PARP15ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL8567413 | 0.72 | SMPD1 (0.52) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL3729542 | 0.72 | RAB9A (0.57) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL7669393 | 0.72 | RAB9A (0.57) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL8425312 | 0.72 | RAB9A (0.65) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL29032297 | 0.71 | POLB (0.41) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12339549 | 0.71 | PARP10 (0.83) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL30418238 | 0.71 | SMPD1 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL7438620 | 0.71 | SMPD1 (0.71) | ALDH1A1MAPTHTTNPC1RAB9A | |
| SCHEMBL11013421 | 0.71 | KDM4E (0.49) | PARP15ALDH1A1MAPTHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |