Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | PARP15 | Q460N3 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693213 | 0.82 | PARP15 (0.46) | FFAR1PARP15ALDH1A1MAPTHTT | |
| SCHEMBL29625514 | 0.75 | TAAR1 (0.58) | PARP15MAPTNPC1RAB9APARP10 | |
| SCHEMBL18614962 | 0.74 | PARP10 (0.52) | FFAR1PARP15MAPTPARP10PARP14 | |
| SCHEMBL9121493 | 0.74 | FFAR1 (0.66) | FFAR1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL29387252 | 0.74 | KDM4E (0.40) | PARP15ALDH1A1HTTNPC1RAB9A | |
| SCHEMBL7669393 | 0.74 | RAB9A (0.57) | FFAR1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL3729542 | 0.74 | RAB9A (0.57) | FFAR1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL8425312 | 0.74 | RAB9A (0.65) | FFAR1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL12339549 | 0.73 | PARP10 (0.83) | FFAR1ALDH1A1MAPTHTTNPC1 | |
| SCHEMBL4294900 | 0.73 | SMN1; SMN2 (0.53) | ALDH1A1HTTNPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521757-B1 | TRICYCLIC SPIROPIPERIDINES OR SPIROPYRROLIDINES | ASTRAZENECA AB (SE) | 2008-01-30 | — | — | EP | disclosed |