Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 7/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.45 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748313 | 0.88 | ALDH1A1 (0.50) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5747586 | 0.88 | ALDH1A1 (0.50) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL3857196 | 0.86 | ALDH1A1 (0.50) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5909080 | 0.85 | VNN1 (0.53) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5909117 | 0.85 | ALDH1A1 (0.52) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5909284 | 0.85 | VNN1 (0.53) | KDM5AKMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5908999 | 0.81 | ALDH1A1 (0.61) | KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL5746443 | 0.81 | ALDH1A1 (0.51) | KDM5AEPHX2KMT2AALDH1A1MEN1 | |
| SCHEMBL3862880 | 0.81 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1KDM5BLMNA | |
| SCHEMBL5746938 | 0.81 | ALDH1A1 (0.53) | KMT2AALDH1A1MEN1KDM5BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680415-B1 | PYRROLIDINYL UREA DERIVATIVES AS ANGIOGENESIS INHIBITORS | ABBOTT LAB (US) | 2008-12-31 | — | — | EP | claimed |