Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19022300 | 0.83 | TACR1 (0.37) | TACR1IDO1 | |
| SCHEMBL722683 | 0.78 | IDO1 (0.49) | IDO1 | |
| SCHEMBL3587231 | 0.77 | IDO1 (0.50) | TACR1IDO1 | |
| SCHEMBL481256 | 0.77 | IDO1 (0.42) | IDO1 | |
| SCHEMBL643942 | 0.74 | — | — | |
| SCHEMBL4801258 | 0.73 | IDO1 (0.56) | TACR1IDO1 | |
| SCHEMBL5442094 | 0.73 | CYP2A6 (0.34) | TACR1 | |
| SCHEMBL2497155 | 0.72 | CA2 (0.34) | — | |
| SCHEMBL21493100 | 0.71 | KMT2A (0.31) | — | |
| SCHEMBL16951081 | 0.70 | TACR1 (0.49) | TACR1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |