Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | FLT1 | P17948 | 4/20 | 0.49 |
| ▸ | MET | P08581 | 13/20 | 0.48 |
| ▸ | AXL | P30530 | 12/20 | 0.47 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | MERTK | Q12866 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | LCK | P06239 | 2/20 | 0.47 |
| ▸ | LYN | P07948 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | HCK | P08631 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | BCR | P11274 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048227 | 0.93 | MET (0.57) | AURKBFLT1METAXLKDR | |
| SCHEMBL469289 | 0.87 | MET (0.63) | AURKBFLT1METAXLKDR | |
| SCHEMBL469348 | 0.87 | AURKB (0.59) | AURKBFLT1METAXLKDR | |
| SCHEMBL469354 | 0.86 | AURKB (0.58) | AURKBFLT1METAXLKDR | |
| SCHEMBL469351 | 0.86 | MET (0.63) | AURKBFLT1METAXLKDR | |
| SCHEMBL469258 | 0.86 | AURKB (0.56) | AURKBFLT1METAXLKDR | |
| SCHEMBL21941634 | 0.84 | MET (0.59) | AURKBFLT1METAXLKDR | |
| SCHEMBL469295 | 0.83 | MET (0.69) | AURKBFLT1METAXLKDR | |
| SCHEMBL21941636 | 0.82 | AURKB (0.50) | AURKBFLT1METAXLKDR | |
| SCHEMBL469356 | 0.81 | AURKB (0.60) | AURKBFLT1METAXLKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012034055-A2 | COMPOUNDS AS C-MET KINASE INHIBITORS | ADVENCHEN LABORATORIES, LLC (US) | 2012-03-15 | — | — | WO | disclosed |