Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 6/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | NPY2R | P49146 | 2/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | PNLIP | P16233 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691406 | 0.91 | HCRTR1 (0.48) | HCRTR1HCRTR2NPY2RALDH1A1MAPT | |
| SCHEMBL4692337 | 0.89 | HCRTR1 (0.51) | HCRTR1HCRTR2ALDH1A1MAPTKDM4E | |
| SCHEMBL4692889 | 0.88 | MAPT (0.45) | HCRTR1HCRTR2ALDH1A1MAPTKDM4E | |
| SCHEMBL4693334 | 0.88 | ALDH1A1 (0.45) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL4693690 | 0.87 | HCRTR1 (0.51) | HCRTR1HCRTR2MGLLLIPENPY2R | |
| SCHEMBL4693018 | 0.87 | NPY2R (0.47) | MGLLNPY2RALDH1A1MAPTKDM4E | |
| SCHEMBL4691905 | 0.86 | HCRTR1 (0.47) | HCRTR1HCRTR2NPY2RALDH1A1MAPT | |
| SCHEMBL4690668 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EGAASMN1; SMN2 | |
| SCHEMBL4693956 | 0.85 | HCRTR1 (0.49) | HCRTR1HCRTR2NPY2RALDH1A1MAPT | |
| SCHEMBL4694235 | 0.85 | ALDH1A1 (0.43) | MGLLALDH1A1MAPTKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |