Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9859507 | 0.88 | MEN1 (0.42) | ALDH1A1TDP1MAPK1CES1CES2 | |
| SCHEMBL9615016 | 0.87 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL9615018 | 0.87 | ALDH1A1 (0.59) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL2832454 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL2832450 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL2832453 | 0.80 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL9592340 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPK1MAPTPOLB | |
| SCHEMBL10456489 | 0.78 | ALDH1A1 (0.50) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL1824861 | 0.76 | TCF4 (0.58) | ALDH1A1TDP1MAPK1CES1TSHR | |
| SCHEMBL1824858 | 0.76 | TCF4 (0.58) | ALDH1A1TDP1MAPK1CES1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284734-B1 | ISOQUINOLINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CUREGENICS LTD (IL) | 2008-05-21 | — | — | EP | disclosed |
| US-6949565-B2 | Protein kinase inhibitors | DEVELOGEN ISRAEL LTD. (IL) | 2005-09-27 | — | — | US | disclosed |
| EP-1284734-A4 | PROTEIN KINASE INHIBITORS | PEPTOR LTD (IL) | 2004-03-10 | — | — | EP | disclosed |
| US-20040019077-A1 | Heterocyclic imines such as N1-(8-sulfonamide-5-isoquinoline)-N2-(3,3-diphenyl-2-propenyl) -ethylenediamine, used for prophylaxis and diagnosis of cancers, diabetes, cardiovascular and nervous system disorders, autoimmune diseases or obesity | CUREGENICS LTD. (IL) | 2004-01-29 | — | — | US | disclosed |
| EP-1284734-A1 | PROTEIN KINASE INHIBITORS | Peptor Ltd. (IL) | 2003-02-26 | — | — | EP | disclosed |
| WO-2001091754-A1 | PROTEIN KINASE INHIBITORS | PEPTOR LTD. (IL) | 2001-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040019077-A1 | Heterocyclic imines such as N1-(8-sulfonamide-5-isoquinoline)-N2-(3,3-diphenyl-2-propenyl) -ethylenediamine, used for prophylaxis and diagnosis of cancers, diabetes, cardiovascular and nervous system disorders, autoimmune diseases or obesity | CHKB, MAP4K2, PKN2 | ALDH1A1 3992/4885TDP1 1617/4885MAPK1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.