Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.62 |
| ▸ | HPGD | P15428 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GCGR | P47871 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.54 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.54 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20248965 | 0.80 | MAPT (0.78) | PTPN5ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2648459 | 0.80 | ALDH1A1 (0.69) | PTPN5ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2644228 | 0.80 | ALDH1A1 (0.72) | ALDH1A1HPGDMAPTSMN1; SMN2POLB | |
| SCHEMBL2644794 | 0.80 | MAPK10 (0.72) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4693720 | 0.79 | ALDH1A1 (0.73) | ALDH1A1HPGDSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1207343 | 0.78 | ALDH1A1 (0.52) | PTPN5ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2644393 | 0.77 | L3MBTL1 (0.67) | ALDH1A1HPGDMAPTSMN1; SMN2POLB | |
| SCHEMBL2648406 | 0.77 | GCGR (0.70) | PTPN5ALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL2643514 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2POLB | |
| SCHEMBL2643746 | 0.76 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTSMN1; SMN2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620425-B1 | SUBSTITUTED 3-CYANOTHIOPHENE ACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-12-24 | — | — | EP | claimed |