Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 20/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936643 | 0.86 | LTA4H (0.56) | LTA4HKCNH2 | |
| SCHEMBL2168385 | 0.86 | LTA4H (0.58) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2167786 | 0.86 | LTA4H (0.56) | LTA4HKCNH2 | |
| SCHEMBL2169020 | 0.85 | LTA4H (0.54) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2167904 | 0.84 | LTA4H (0.56) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2169597 | 0.83 | LTA4H (0.55) | LTA4HKCNH2EPHX2 | |
| SCHEMBL4693779 | 0.82 | LTA4H (0.54) | LTA4HKCNH2EPHX2 | |
| SCHEMBL4693774 | 0.82 | LTA4H (0.59) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2168410 | 0.82 | LTA4H (0.52) | LTA4HKCNH2EPHX2 | |
| SCHEMBL2170463 | 0.81 | LTA4H (0.54) | LTA4HKCNH2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660492-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-20 | — | — | EP | claimed |