Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F3 | P13726 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4690837 | 0.91 | DHFR (0.45) | DHFRSLC2A1F2R | |
| Trifluoroacetic Acid SCHEMBL4693910 | 0.89 | DHFR (0.41) | DHFRSLC2A1PAX8 | |
| Trifluoroacetic Acid SCHEMBL4692155 | 0.88 | DHFR (0.40) | DHFRADORA2ASLC2A1PAX8 | |
| Trifluoroacetic Acid SCHEMBL4689915 | 0.88 | SLC2A1 (0.41) | DHFRADORA2ASLC2A1PAX8 | |
| Trifluoroacetic Acid SCHEMBL4687967 | 0.88 | SLC2A1 (0.41) | DHFRSLC2A1F2RPAX8KDR | |
| Trifluoroacetic Acid SCHEMBL4692005 | 0.87 | MAP4K4 (0.41) | DHFRSLC2A1 | |
| Trifluoroacetic Acid SCHEMBL4692244 | 0.87 | DHFR (0.42) | DHFRADORA2ASLC2A1PAX8 | |
| Trifluoroacetic Acid SCHEMBL4690937 | 0.86 | DHFR (0.52) | DHFRSLC2A1PAX8KDR | |
| Trifluoroacetic Acid SCHEMBL4687242 | 0.86 | DHFR (0.40) | DHFRSLC2A1F2R | |
| SCHEMBL27634076 | 0.86 | DHFR (0.44) | DHFRSLC2A1F2RPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628979-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-03-19 | — | — | EP | disclosed |
| US-20070270445-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | BERTHEL STEVEN J | 2007-11-22 | — | — | US | disclosed |
| US-7262297-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-08-28 | — | — | US | disclosed |
| US-20040235872-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | BERTHEL STEVEN JOSEPH (US) | 2004-11-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235872-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | PTPN5, PPP5C, PTP4A2 | DHFR 289/4885ADORA2A 2090/4885SLC2A1 271/4885 |
| US-20070270445-A1 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | PTPN5, DUSP15, PPP5C | DHFR 339/4885ADORA2A 1770/4885SLC2A1 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.