Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.43 |
| ▸ | DRD2 | P14416 | 11/20 | 0.42 |
| ▸ | DRD4 | P21917 | 11/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4692997 | 0.90 | SMYD2 (0.41) | DRD3DRD2DRD4SMYD2 | |
| SCHEMBL4693959 | 0.90 | HCRTR1 (0.45) | DRD3DRD2DRD4SIGMAR1SMYD2 | |
| SCHEMBL3284096 | 0.88 | SMYD2 (0.44) | DRD3DRD2DRD4SMYD2 | |
| SCHEMBL4694080 | 0.87 | HCRTR1 (0.40) | DRD3DRD2DRD4SIGMAR1 | |
| SCHEMBL4691761 | 0.86 | SLC6A2 (0.44) | DRD3DRD2DRD4SMYD2 | |
| SCHEMBL4691218 | 0.86 | DRD2 (0.45) | DRD3DRD2DRD4CYP2D6CYP2C9 | |
| SCHEMBL4692672 | 0.86 | SMYD2 (0.45) | DRD3DRD2DRD4SMYD2 | |
| SCHEMBL4693332 | 0.85 | SLC6A4 (0.45) | DRD3DRD2DRD4SIGMAR1SMYD2 | |
| SCHEMBL4692216 | 0.85 | SLC6A2 (0.43) | DRD3DRD2DRD4SMYD2 | |
| SCHEMBL4692347 | 0.84 | DRD2 (0.42) | DRD3DRD2DRD4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |