Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247315 | 0.86 | ADORA2A (0.37) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL15577115 | 0.82 | ALOX5 (0.34) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL6334980 | 0.81 | ADORA2A (0.35) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL4478147 | 0.73 | CYP1A2 (0.31) | — | |
| SCHEMBL4477931 | 0.69 | CSNK2A1 (0.34) | — | |
| SCHEMBL4463886 | 0.69 | ERN1 (0.33) | ERN1 | |
| SCHEMBL6336378 | 0.69 | ERN1 (0.30) | ADORA2BERN1ADORA1 | |
| SCHEMBL4473652 | 0.69 | CYP1A1 (0.35) | ERN1FYNPPARGPLAU | |
| SCHEMBL5737770 | 0.68 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL17592087 | 0.66 | ERN1 (0.33) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646626-B1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2008-07-02 | — | — | EP | claimed |
| US-20060235015-A1 | Pyrrole-2,5-dione derivatives as liver x receptor modulators | ASTRAZENECA AB (SE) | 2006-10-19 | — | — | US | claimed |
| CN-1823061-A | Pyrrole-2, 5-dione derivatives as liver X receptor modulators | ASTRAZENECA AB (SE) | 2006-08-23 | — | — | CN | claimed |
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | claimed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | claimed |
| US-7432288-B2 | Pyrrole-2,5-dione derivatives as Liver X receptor modulators | ASTRAZENECA AB (SE) | 2008-10-07 | — | — | US | disclosed |
| EP-1646626-B1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| US-20060235015-A1 | Pyrrole-2,5-dione derivatives as liver x receptor modulators | ASTRAZENECA AB (SE) | 2006-10-19 | — | — | US | disclosed |
| CN-1823061-A | Pyrrole-2, 5-dione derivatives as liver X receptor modulators | ASTRAZENECA AB (SE) | 2006-08-23 | — | — | CN | disclosed |
| EP-1646626-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2006-04-19 | — | — | EP | disclosed |
| WO-2005005417-A1 | PYRROLE-2, 5-DIONE DERIVATIVES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2005-01-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235015-A1 | Pyrrole-2,5-dione derivatives as liver x receptor modulators | NR1H2, NR1H3, SREBF2 | ADORA2A 1167/4885ADORA3 2048/4885ADORA2B 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.