Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 3/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.31 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.31 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5737770 | 0.68 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL6334980 | 0.68 | ADORA2A (0.35) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL15577115 | 0.68 | ALOX5 (0.34) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL30837248 | 0.64 | HSD17B1 (0.55) | ADORA2AADORA3ADORA2BERN1FYN | |
| SCHEMBL277930 | 0.63 | — | — | |
| SCHEMBL27295193 | 0.63 | ADORA3 (0.36) | ADORA2AADORA3ADORA2BCNR2FYN | |
| SCHEMBL11483469 | 0.63 | PTGER2 (0.38) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| Acetic Acid SCHEMBL28427938 | 0.62 | CNR1 (0.45) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL27649048 | 0.61 | BACE1 (0.44) | ADORA2AADORA3ADORA2BCNR2ERN1 | |
| SCHEMBL2088791 | 0.61 | CA5A (0.50) | CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1832586-A1 | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas | Oridis Biomed Forschungs- und Entwicklungs GmbH (AT) | 2007-09-12 | — | — | EP | claimed |
| EP-1832586-A1 | Thiazole-piperidine derivatives in treatment of diseases of liver and the pancreas | Oridis Biomed Forschungs- und Entwicklungs GmbH (AT) | 2007-09-12 | — | — | EP | disclosed |