SCHEMBL4694766

SCHEMBL4694766

CNC(=O)c1ccc2c(c1)OC(c1ccccc1)(c1ccccc1)O2

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 5/20 0.56
IP6K1 Q92551 1/20 0.48
IP6K3 Q96PC2 1/20 0.48
IP6K2 Q9UHH9 1/20 0.48
SRD5A1 P18405 2/20 0.47
SRD5A2 P31213 2/20 0.47
CTNNB1 P35222 1/20 0.43
WNT3A P56704 1/20 0.43
BRD4 O60885 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
NPC1 O15118 2/20 0.40
PKM P14618 2/20 0.40
RAB9A P51151 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
NFKB1 P19838 1/20 0.40
MAOB P27338 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30257325 0.83 CNR1 (0.63) CNR1IP6K1IP6K3IP6K2SRD5A1
SCHEMBL8728950 0.83 CNR1 (0.63) CNR1IP6K1IP6K3IP6K2SRD5A1
SCHEMBL9040996 0.81 CNR1 (0.62) CNR1IP6K1IP6K3IP6K2SRD5A1
SCHEMBL9144238 0.80 CNR1 (0.60) CNR1SRD5A1SRD5A2CTNNB1WNT3A
SCHEMBL8728849 0.80 CNR1 (0.60) CNR1SRD5A1SRD5A2CTNNB1WNT3A
SCHEMBL26208395 0.80 SMN1; SMN2 (0.47) IP6K1IP6K3IP6K2HDAC8HDAC6
SCHEMBL6812882 0.79 CNR1 (0.56) CNR1SRD5A1SRD5A2CTNNB1WNT3A
Lithium Ion SCHEMBL9040989 0.79 CNR1 (0.59) CNR1SRD5A1SRD5A2CTNNB1WNT3A
SCHEMBL30376331 0.78 SMYD3 (0.57) CTNNB1WNT3AHDAC8HDAC6
SCHEMBL13875364 0.78 CNR1 (0.58) CNR1SRD5A1SRD5A2CTNNB1WNT3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1532132-B1 NOVEL BENZODIOXOLES HOFFMANN LA ROCHE (CH) 2008-03-19 EP claimed
EP-1532132-B1 NOVEL BENZODIOXOLES HOFFMANN LA ROCHE (CH) 2008-03-19 EP disclosed
EP-0535192-B1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME HOFFMANN LA ROCHE (CH) 1996-06-19 EP disclosed
US-5486466-A ENZYME INHIBITORS HOFFMANN-LA ROCHE INC. (US) 1996-01-23 US disclosed
US-5399741-A DNA gyrase inhibitors, process for their manufacture and pharmaceutical preparations containing same HOFFMANN-LA ROCHE INC. (US) 1995-03-21 US disclosed
US-5294609-A Microbiocides HOFFMANN-LAROCHE INC. (US) 1994-03-15 US disclosed
EP-0535192-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME. HOFFMANN LA ROCHE (CH) 1993-04-07 EP disclosed
WO-1992018490-A1 NOVEL DNA GYRASE INHIBITORS, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME F. HOFFMANN-LA ROCHE AG (CH) 1992-10-29 WO disclosed