Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694813 | 0.93 | CYP1A2 (0.48) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL4694236 | 0.92 | EPHX2 (0.44) | KMT2AMEN1MAPTLMNAEPHX2 | |
| SCHEMBL4694761 | 0.92 | LMNA (0.49) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL3281859 | 0.91 | CCR5 (0.52) | KMT2AMEN1LMNAGAAMAPK1 | |
| SCHEMBL4695646 | 0.90 | KMT2A (0.48) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL4694161 | 0.90 | KMT2A (0.48) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL4691903 | 0.90 | MEN1 (0.55) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL4693537 | 0.89 | MAPT (0.48) | KMT2AMEN1MAPTLMNAPOLB | |
| SCHEMBL4690401 | 0.87 | TP53 (0.47) | KMT2AMAPTLMNAPOLBCYP2C9 | |
| SCHEMBL4694331 | 0.87 | TP53 (0.47) | KMT2AMAPTLMNAPOLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |