⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2458974 | 0.84 | — | — | |
| SCHEMBL9849643 | 0.83 | — | — | |
| SCHEMBL2636758 | 0.77 | — | — | |
| SCHEMBL7821844 | 0.77 | — | — | |
| SCHEMBL5133399 | 0.76 | MAPK1 (0.31) | — | |
| SCHEMBL28222967 | 0.76 | — | — | |
| SCHEMBL6410731 | 0.74 | — | — | |
| SCHEMBL6863642 | 0.74 | — | — | |
| SCHEMBL20817269 | 0.73 | — | — | |
| SCHEMBL7857026 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112566906-B | Substituted quinazolinone derivatives and their use as positive allosteric modulators of MGLUR4 | 多曼治疗学公司 | 2024-11-12 | — | — | CN | disclosed |
| CN-112566906-A | Substituted quinazolinone derivatives and their use as positive allosteric modulators of MGLUR4 | 多曼治疗学公司 | 2021-03-26 | — | — | CN | disclosed |
| CN-110088086-A | Disubstituted maleic amide class connexon and its preparation method and application for antibody-drug conjugate | 迈威(上海)生物科技有限公司 | 2019-08-02 | — | — | CN | disclosed |
| CN-109810039-A | Disubstituted maleimide-based linker for antibody-drug coupling, preparation method and application thereof | 上海青润医药科技有限公司 | 2019-05-28 | — | — | CN | disclosed |
| EP-1053227-B1 | PPAR-GAMMA MODULATORS | AMGEN INC (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |