Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 14/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696921 | 0.92 | CCR5 (0.47) | CCR5ITGB1ITGA4SLC6A9UTS2R | |
| SCHEMBL4695320 | 0.86 | CCR5 (0.41) | CCR5SLC6A9 | |
| SCHEMBL4696469 | 0.83 | CCR5 (0.41) | CCR5UTS2R | |
| SCHEMBL4694831 | 0.83 | CCR5 (0.41) | CCR5 | |
| SCHEMBL4694830 | 0.83 | CCR5 (0.41) | CCR5 | |
| SCHEMBL4696511 | 0.82 | CCR5 (0.40) | CCR5P2RX7 | |
| SCHEMBL4696815 | 0.82 | CCR5 (0.40) | CCR5 | |
| SCHEMBL4690656 | 0.80 | CCR5 (0.43) | CCR5 | |
| SCHEMBL4690148 | 0.79 | CCR5 (0.67) | CCR5 | |
| SCHEMBL4690158 | 0.79 | CCR5 (0.67) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |