Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 11/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4693596 | 0.90 | CNR1 (0.59) | CNR1PTPN11CNR2HDAC3HDAC4 | |
| SCHEMBL4691863 | 0.80 | CNR1 (0.48) | CNR1CNR2 | |
| SCHEMBL4695350 | 0.72 | CNR1 (0.79) | CNR1PTPN11CNR2 | |
| SCHEMBL31558410 | 0.69 | CNR2 (0.42) | CNR1CNR2 | |
| SCHEMBL4691408 | 0.69 | CNR1 (0.59) | CNR1CNR2 | |
| SCHEMBL14545361 | 0.68 | CNR1 (0.91) | CNR1CNR2 | |
| SCHEMBL4693638 | 0.67 | KMT2A (0.40) | CNR2 | |
| SCHEMBL3056017 | 0.67 | ALDH1A1 (0.54) | PTPN11 | |
| SCHEMBL14523362 | 0.67 | CKS1B (0.58) | PTPN11 | |
| SCHEMBL4748379 | 0.67 | CNR1 (0.61) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871762-A2 | SUBTITUTED HETEROARYL CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006113704-A2 | SUBTITUTED HETEROARYL CB1 ANTAGONISTS | NEUROGEN CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |