Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695915 | 0.83 | EPHX2 (0.47) | MMP13TP53GPR119EPHX2MEN1 | |
| SCHEMBL4162073 | 0.81 | BDKRB1 (0.52) | — | |
| SCHEMBL4177058 | 0.75 | BDKRB1 (0.53) | — | |
| SCHEMBL4173221 | 0.75 | BDKRB1 (0.53) | — | |
| SCHEMBL4186841 | 0.71 | BDKRB1 (0.53) | — | |
| SCHEMBL4173208 | 0.71 | BDKRB1 (0.53) | — | |
| SCHEMBL4180773 | 0.67 | BDKRB1 (0.72) | — | |
| SCHEMBL216692 | 0.67 | GPR119 (0.58) | MMP13TP53GPR119KDM4EMEN1 | |
| SCHEMBL10265584 | 0.66 | GPR119 (0.57) | MMP13TP53GPR119KDM4EEPHX2 | |
| SCHEMBL4172644 | 0.66 | BDKRB1 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |