Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 7/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695873 | 0.83 | MMP13 (0.40) | EPHX2MMP13TP53GPR119KMT2A | |
| SCHEMBL4180773 | 0.79 | BDKRB1 (0.72) | BDKRB1 | |
| SCHEMBL2961651 | 0.69 | MMP13 (0.62) | EPHX2MMP13GPR119KMT2AMEN1 | |
| SCHEMBL4172644 | 0.69 | BDKRB1 (0.57) | BDKRB1 | |
| SCHEMBL4173494 | 0.69 | BDKRB1 (0.74) | BDKRB1 | |
| SCHEMBL4699666 | 0.69 | BDKRB1 (0.74) | BDKRB1 | |
| SCHEMBL4173491 | 0.69 | BDKRB1 (0.74) | BDKRB1 | |
| SCHEMBL216692 | 0.69 | GPR119 (0.58) | MMP13TP53GPR119KMT2AMEN1 | |
| SCHEMBL10265584 | 0.68 | GPR119 (0.57) | EPHX2MMP13TP53GPR119KMT2A | |
| SCHEMBL23012558 | 0.68 | MMP13 (0.63) | EPHX2MMP13GPR119KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963285-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | Amgen Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007067629-A1 | BRADYKININ 1 RECEPTOR ANTAGONISTS | AMGEN INC. (US) | 2007-06-14 | — | — | WO | disclosed |