Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 6/20 | 0.47 |
| ▸ | PROKR1 | Q8TCW9 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696048 | 0.83 | FPR2 (0.48) | FPR2PROKR1GAA | |
| SCHEMBL3283550 | 0.79 | SMN1; SMN2 (0.49) | LMNASMN1; SMN2NPC1MAPK14KDM4E | |
| SCHEMBL4694263 | 0.78 | SLC6A2 (0.51) | GAAKDM4EKMT2A | |
| SCHEMBL4690478 | 0.77 | MEN1 (0.41) | LMNASMN1; SMN2NPC1GAAMAPK14 | |
| SCHEMBL4691639 | 0.77 | SMYD2 (0.48) | LMNASMN1; SMN2KDM4EDRD2DRD4 | |
| SCHEMBL4691221 | 0.77 | L3MBTL3 (0.45) | LMNASMN1; SMN2GAARAD52MAPK14 | |
| SCHEMBL4694306 | 0.76 | FPR2 (0.56) | FPR2PROKR1 | |
| SCHEMBL4693332 | 0.75 | SLC6A4 (0.45) | LMNASMN1; SMN2GAAKDM4EDRD2 | |
| SCHEMBL4690666 | 0.75 | NTRK1 (0.44) | LMNASMN1; SMN2GAAMAPK14KMT2A | |
| SCHEMBL4694269 | 0.75 | HCRTR1 (0.48) | LMNASMN1; SMN2GAAMAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-A2 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | claimed |
| WO-2005121145-A2 | OCTAHYDRO-PYRROLO[3,4-C] DERIVATIVES AND THEIR USE AS ANTIVIRAL COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |