Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 8/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4691824 | 0.93 | CCR5 (0.42) | CCR5MEN1KMT2AUTS2RDGAT2 | |
| SCHEMBL4694537 | 0.93 | CCR5 (0.44) | CCR5UTS2RROCK2ROCK1DGAT2 | |
| SCHEMBL4690858 | 0.92 | CCR5 (0.48) | CCR5UTS2RROCK2ROCK1DGAT2 | |
| SCHEMBL4696387 | 0.91 | CCR5 (0.47) | CCR5UTS2RROCK2ROCK1 | |
| SCHEMBL4694765 | 0.91 | CCR5 (0.44) | CCR5UTS2RROCK2ROCK1DGAT2 | |
| SCHEMBL4691949 | 0.91 | UTS2R (0.49) | CCR5UTS2RROCK2ROCK1KDM4E | |
| SCHEMBL4690588 | 0.89 | CCR5 (0.48) | CCR5 | |
| SCHEMBL4695072 | 0.89 | CCR5 (0.43) | CCR5UTS2RROCK2ROCK1DGAT2 | |
| SCHEMBL4691378 | 0.89 | CCR5 (0.43) | CCR5MEN1KMT2AUTS2RROCK2 | |
| SCHEMBL4690226 | 0.88 | CCR5 (0.46) | CCR5UTS2RITGB1ITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | claimed |
| EP-1761542-B1 | OCTAHYDROPYRROLO[3,4-C]PYRROLE DERIVATIVES AN THEIR USE AS ANTIVIRAL AGENTS | HOFFMANN LA ROCHE (CH) | 2008-01-02 | — | — | EP | disclosed |