Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4695757 | 0.89 | CD274 (0.39) | PDCD1CD274 | |
| SCHEMBL4696628 | 0.89 | HDAC1 (0.35) | PDCD1CD274 | |
| SCHEMBL6027369 | 0.84 | OPRM1 (0.37) | PDCD1CD274 | |
| SCHEMBL4695712 | 0.84 | MEN1 (0.38) | PDCD1CD274 | |
| SCHEMBL4696800 | 0.83 | CD274 (0.42) | PDCD1CD274 | |
| SCHEMBL4693066 | 0.82 | KDM4E (0.34) | PDCD1CD274 | |
| SCHEMBL4695640 | 0.81 | PDCD1 (0.34) | PDCD1CD274 | |
| SCHEMBL5803928 | 0.80 | MAOB (0.35) | PDCD1CD274 | |
| SCHEMBL4696335 | 0.79 | PDCD1 (0.44) | PDCD1CD274 | |
| SCHEMBL4695511 | 0.78 | PDCD1 (0.34) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | disclosed |