Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 19/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 17/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6027369 | 0.92 | OPRM1 (0.37) | CD274PDCD1 | |
| SCHEMBL4696348 | 0.89 | PDCD1 (0.38) | CD274PDCD1 | |
| SCHEMBL4696335 | 0.88 | PDCD1 (0.44) | CD274PDCD1HTTSMN1; SMN2 | |
| SCHEMBL4695712 | 0.85 | MEN1 (0.38) | CD274PDCD1 | |
| SCHEMBL4696800 | 0.84 | CD274 (0.42) | CD274PDCD1HTTSMN1; SMN2 | |
| SCHEMBL4692560 | 0.82 | CD274 (0.39) | CD274PDCD1 | |
| SCHEMBL4695001 | 0.81 | CD274 (0.46) | CD274PDCD1HTTSMN1; SMN2 | |
| SCHEMBL4697200 | 0.81 | HDAC1 (0.37) | CD274PDCD1 | |
| SCHEMBL5803928 | 0.81 | MAOB (0.35) | CD274PDCD1 | |
| SCHEMBL4692679 | 0.80 | PDCD1 (0.41) | CD274PDCD1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893577-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | Theravance, Inc. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006138218-A1 | BIPHENYL COMPOUNDS USEFUL AS MUSCARINIC RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2006-12-28 | — | — | WO | claimed |