SCHEMBL4696476

SCHEMBL4696476

COc1cccc(C)c1NBr

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.47
CYP3A4 P08684 3/20 0.47
CYP1A2 P05177 2/20 0.47
CYP2C19 P33261 2/20 0.47
ATM Q13315 1/20 0.46
ALDH1A1 P00352 2/20 0.44
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA4 P22748 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
KMT2A Q03164 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
PKM P14618 2/20 0.40
FFAR4 Q5NUL3 1/20 0.40
MAPT P10636 3/20 0.39
LMNA P02545 2/20 0.39
KDM4E B2RXH2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28208492 0.87 CA1 (0.50) TAAR1CYP3A4CYP1A2CYP2C19ALDH1A1
SCHEMBL15883199 0.81 ALDH1A1 (0.55) TAAR1CYP3A4CYP1A2CYP2C19ATM
SCHEMBL11664862 0.81 TAAR1 (0.49) TAAR1CYP3A4CYP1A2CYP2C19ATM
SCHEMBL3821152 0.79 CYP1A2 (0.43) CYP1A2CYP2C19ATMALDH1A1CA1
SCHEMBL3860721 0.79 TAAR1 (0.47) TAAR1CYP3A4CYP1A2CYP2C19ATM
Hydrochloric Acid SCHEMBL30144043 0.78 TAAR1 (0.46) TAAR1CYP3A4CYP1A2CYP2C19ATM
Hydrochloric Acid SCHEMBL11901803 0.78 TAAR1 (0.46) TAAR1CYP3A4CYP1A2CYP2C19ATM
SCHEMBL14017796 0.76 ATM (0.47) TAAR1CYP3A4CYP1A2CYP2C19ATM
SCHEMBL11659570 0.76 TAAR1 (0.45) TAAR1CYP3A4CYP1A2CYP2C19ATM
SCHEMBL24834185 0.76 ATM (0.48) TAAR1CYP3A4CYP1A2CYP2C19ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1960355-A1 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES F.HOFFMANN-LA ROCHE AG (CH) 2008-08-27 EP disclosed
WO-2007062996-A1 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES F. HOFFMANN-LA ROCHE AG (CH) 2007-06-07 WO disclosed