Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 16/20 | 0.75 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | FGR | P09769 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | SIK1 | P57059 | 1/20 | 0.45 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | TSSK2 | Q96PF2 | 1/20 | 0.45 |
| ▸ | WNK3 | Q9BYP7 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3766966 | 0.86 | NTRK1 (1.00) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL4750903 | 0.83 | NTRK1 (0.79) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL56800 | 0.83 | NTRK1 (0.79) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL57147 | 0.83 | NTRK1 (0.56) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL4699080 | 0.83 | NTRK1 (0.52) | NTRK1JAK2MAPK1 | |
| SCHEMBL3774702 | 0.82 | NTRK1 (1.00) | NTRK1JAK2ALKABL1FGR | |
| SCHEMBL4697335 | 0.81 | NTRK1 (0.63) | NTRK1JAK2IGF1R | |
| SCHEMBL4695287 | 0.80 | NTRK1 (0.62) | NTRK1JAK2IGF1R | |
| SCHEMBL4694035 | 0.79 | NTRK1 (0.54) | NTRK1JAK2IGF1R | |
| SCHEMBL4694696 | 0.75 | NTRK1 (0.50) | NTRK1JAK2PAK1PAK3PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |