Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.54 |
| ▸ | IGF1R | P08069 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698219 | 0.77 | NTRK1 (0.59) | NTRK1IGF1RJAK2PIM1 | |
| SCHEMBL4694151 | 0.72 | NTRK1 (0.55) | NTRK1IGF1RJAK2PIM1 | |
| SCHEMBL4693854 | 0.71 | NTRK1 (0.59) | NTRK1JAK2 | |
| SCHEMBL3774702 | 0.70 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL11932347 | 0.67 | IGF1R (1.00) | NTRK1IGF1R | |
| SCHEMBL4695215 | 0.65 | NUAK1 (0.61) | NTRK1IGF1R | |
| SCHEMBL27513658 | 0.61 | CYP1A2 (1.00) | CYP1A2APPMKNK1 | |
| SCHEMBL27709595 | 0.61 | NTRK1 (0.68) | NTRK1 | |
| SCHEMBL12128975 | 0.61 | CYP1A2 (0.59) | CYP1A2APPPIM1MKNK1 | |
| SCHEMBL57147 | 0.61 | NTRK1 (0.56) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |