Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | PDE1C | Q14123 | 7/20 | 0.42 |
| ▸ | LCK | P06239 | 6/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696570 | 0.83 | NTRK1 (0.75) | NTRK1MAPK1JAK2 | |
| SCHEMBL57014 | 0.82 | NTRK1 (0.55) | NTRK1LCKJAK2 | |
| SCHEMBL4694092 | 0.75 | NTRK1 (0.48) | NTRK1 | |
| SCHEMBL4696400 | 0.72 | NTRK1 (0.46) | NTRK1PDE1CJAK2 | |
| SCHEMBL4697195 | 0.71 | NTRK1 (0.47) | NTRK1MAPK1 | |
| SCHEMBL56396 | 0.69 | NTRK1 (0.53) | NTRK1JAK2 | |
| SCHEMBL57840 | 0.69 | NTRK1 (0.59) | NTRK1MAPK1JAK2 | |
| SCHEMBL3766966 | 0.69 | NTRK1 (1.00) | NTRK1JAK2 | |
| SCHEMBL4696446 | 0.69 | NTRK1 (0.49) | NTRK1JAK2 | |
| SCHEMBL22535327 | 0.68 | PAK1 (0.48) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |