Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 8/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25735784 | 0.89 | AR (0.50) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL4697051 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL15716165 | 0.85 | XDH (0.41) | ALDH1A1KDM4EUSP2ARMAOB | |
| SCHEMBL11158058 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL26179844 | 0.83 | S1PR1 (0.46) | S1PR1 | |
| SCHEMBL14045403 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL13461882 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL7670516 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL1329661 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 | |
| SCHEMBL29805087 | 0.82 | AR (0.58) | ALDH1A1KDM4EUSP2IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463501-B1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| EP-1463501-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2004-10-06 | — | — | EP | disclosed |
| US-6617346-B1 | Inhibit the interaction of MDM2 protein with a p53-like peptide and have antiproliferative activity | HOFFMANN-LA ROCHE INC. | 2003-09-09 | — | — | US | disclosed |
| WO-2003051360-A1 | CIS-IMIDAZOLINES AS MDM2 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-06-26 | — | — | WO | disclosed |