Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
| ▸ | PPOX | P50336 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932928 | 0.81 | LMNA (0.51) | TDP1MEN1KMT2AHPGDLMNA | |
| SCHEMBL16866217 | 0.81 | HPGD (0.55) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL31090851 | 0.80 | LMNA (0.62) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL14677574 | 0.80 | LMNA (0.62) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10980033 | 0.80 | MAPT (0.61) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL4693866 | 0.79 | HPGD (0.55) | TDP1MEN1KMT2ATTRHPGD | |
| SCHEMBL5719955 | 0.79 | TDP1 (0.61) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL4697665 | 0.78 | L3MBTL1 (0.56) | MEN1KMT2AHPGDLMNASMN1; SMN2 | |
| SCHEMBL4697642 | 0.78 | PPARG (0.52) | MEN1KMT2AEPAS1MAPTNPSR1 | |
| SCHEMBL31090831 | 0.78 | MAPT (0.60) | TDP1MEN1KMT2ATTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1053227-B1 | PPAR-GAMMA MODULATORS | AMGEN INC (US) | 2008-11-05 | — | — | EP | disclosed |
| US-6200995-B1 | PYRIDYLOXYBENZENESULFONAMIDE DERIVATIVES; DIABETES, OBESITY | TULARIK INC. | 2001-03-13 | — | — | US | disclosed |