Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 3/20 | 0.85 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.85 |
| ▸ | NR3C2 | P08235 | 5/20 | 0.85 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.85 |
| ▸ | PGR | P06401 | 3/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.85 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.85 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.85 |
| ▸ | MAPT | P10636 | 2/20 | 0.85 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.85 |
| ▸ | SHBG | P04278 | 2/20 | 0.85 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | AR | P10275 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrocortisone SCHEMBL5084685 | 0.98 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL29263567 | 0.98 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL28435897 | 0.98 | HIF1A (0.82) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7142721 | 0.98 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7144941 | 0.98 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL4886137 | 0.98 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL7137205 | 0.98 | HIF1A (0.81) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL4697 | 0.96 | HIF1A (0.86) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL28908729 | 0.96 | HIF1A (0.86) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 | |
| Hydrocortisone SCHEMBL27961626 | 0.95 | HIF1A (0.85) | HIF1ANR3C2SMN1; SMN2NR3C1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7126 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103492-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2026-04-16 | — | — | US | claimed |
| US-12421281-B2 | Cyclosporine compositions and methods of use | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-09-23 | — | — | US | claimed |
| US-20250288585-A1 | SYNERGISTIC COMPOSITIONS FOR ENHANCED HAIR GROWTH AND METHODS FOR TREATING HAIR LOSS | THE JOHNS HOPKINS UNIVERSITY | 2025-09-18 | — | — | US | claimed |
| US-20250179121-A1 | CYCLOSPORINE COMPOSITIONS AND METHODS OF USE | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-06-05 | — | — | US | claimed |
| WO-2025090570-A1 | ANTI-OX40L ANTIBODIES AND METHODS OF USE | ABCELLERA BIOLOGICS INC. (CA) | 2025-05-01 | — | — | WO | claimed |
| WO-2025085674-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF ULCERATIVE COLITIS | BACAINN THERAPEUTICS, INC. (US) | 2025-04-24 | — | — | WO | claimed |
| US-20250099498-A1 | STRONTIUM BASED COMPOSITIONS AND FORMULATIONS FOR PAIN, PRURITUS, AND INFLAMMATION | GALLEON LABS LLC (US) | 2025-03-27 | — | — | US | claimed |
| US-12252556-B2 | Cyclosporine compositions and methods of use | BACAINN BIOTHERAPEUTICS, LTD. (KY) | 2025-03-18 | — | — | US | claimed |
| US-20250025479-A1 | TRANSPORE DELIVERY OF STEROIDS AND LARGE MOLECULES | STUDIN JOEL (US) | 2025-01-23 | — | — | US | claimed |
| EP-4475851-A1 | FORMULATIONS FOR TRANSDERMAL ADMINISTRATION OF ACTIVE AGENTS | Dyve Biosciences, Inc. (US) | 2024-12-18 | — | — | EP | claimed |
| US-5215965-A | Administering corticosteroid and at least one serine protease inhibitor, its salt or derivatives which bind with the mediators of mast or T-cells | SONORAN DESERT CHEMICALS CORP. LLC | 1993-06-01 | — | — | US | claimed |
| US-5190917-A | Mast cell and T-cell inhibitor | LEZDEY, JARETT | 1993-03-02 | — | — | US | claimed |
| US-5061700-A | SOLVENTS FOR CORTICOSTEROIDS | Dow, Gordon Jay (US) | 1991-10-29 | — | — | US | claimed |
| WO-1991007169-A1 | GLYCERYL ACETATE OINTMENT VEHICLES | DOW GORDON JAY (US) | 1991-05-30 | — | — | WO | claimed |
| US-4992478-A | Antiinflammatory skin moisturizing composition and method of preparing same | WARNER-LAMBERT COMPANY (US) | 1991-02-12 | — | — | US | claimed |
| EP-0391033-A2 | Retinal, derivatives and their therapeutic use | Yu, Ruey J., Dr. (US) | 1990-10-10 | — | — | EP | claimed |
| EP-0336902-A2 | Antiinflammatory skin moisturizing composition and method of preparing same | WARNER-LAMBERT COMPANY (US) | 1989-10-11 | — | — | EP | claimed |
| US-4797402-A | CORTICOSTEROIDS, PEPPERMINT, UREA | DORSEY KENNETH E (US) | 1989-01-10 | — | — | US | claimed |
| US-4244942-A | Creamy preparation containing steroid and process for the preparation thereof | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1981-01-13 | — | — | US | claimed |
| US-4137311-A | CORTICOSTEROIDS, METAL ADDUCTS OF BIS(2-PYRIDYL-1-OXIDE)-DISULFIDE; DERMATITIS, ANTIINFLAMMATORY | WILLIAM H. RORER, INC. (US) | 1979-01-30 | — | — | US | claimed |