Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 8/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21452007 | 0.98 | CA1 (0.50) | CA1FFAR1FFAR4ACE2GPR84 | |
| SCHEMBL12295119 | 0.94 | CA1 (0.46) | CA1CA2 | |
| SCHEMBL9462522 | 0.86 | HSD17B10 (0.41) | CA1CA2 | |
| SCHEMBL20987770 | 0.82 | CA2 (0.50) | CA1FFAR1FFAR4GPR84CA2 | |
| SCHEMBL21250716 | 0.82 | CA2 (0.50) | CA1FFAR1FFAR4GPR84CA2 | |
| SCHEMBL13963511 | 0.82 | ACE2 (0.46) | CA1FFAR1FFAR4ACE2GPR84 | |
| SCHEMBL23082924 | 0.81 | CA2 (0.53) | CA1FFAR1GPR84CA2 | |
| SCHEMBL8233988 | 0.81 | GPR84 (0.57) | FFAR1FFAR4GPR84CA2 | |
| SCHEMBL8240572 | 0.81 | GPR84 (0.57) | FFAR1FFAR4GPR84CA2 | |
| SCHEMBL9849654 | 0.80 | CA1 (0.47) | CA1FFAR1FFAR4ACE2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910374-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | Vernalis (R&D) Limited (GB) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007007069-A1 | AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC SODIUM CHANNELS | VERNALIS (R & D) LIMITED (GB) | 2007-01-18 | — | — | WO | disclosed |