Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL221302 | 0.81 | KMT2A (0.42) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL31220653 | 0.71 | RXFP1 (0.45) | MAPTTP53RAB9ANPC1 | |
| SCHEMBL221181 | 0.69 | RAB9A (0.51) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL4319319 | 0.68 | PARP1 (0.52) | PARP1GPR119 | |
| SCHEMBL219507 | 0.68 | GPR119 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL27770701 | 0.67 | PARP1 (0.52) | PARP1GPR119 | |
| SCHEMBL4788535 | 0.67 | GPR119 (0.39) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL30110406 | 0.67 | PARP1 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1PARP1 | |
| SCHEMBL5043442 | 0.66 | GPR119 (0.43) | GPR119 | |
| SCHEMBL873458 | 0.66 | PARP1 (0.54) | PARP1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910385-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019346-A1 | BENZOTHIAZOLES AND THIAZOLOPYRIDINES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |