Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697442 | 1.00 | CRHR1 (0.42) | CRHR1GABRG2GABRB3GABRA2KDM4E | |
| Hydrochloric Acid SCHEMBL4698416 | 0.99 | CRHR1 (0.42) | CRHR1GABRG2GABRB3GABRA2KDM4E | |
| Hydrochloric Acid SCHEMBL4698414 | 0.99 | CRHR1 (0.42) | CRHR1GABRG2GABRB3GABRA2KDM4E | |
| SCHEMBL14409410 | 0.83 | KDM4E (0.37) | KDM4EALDH1A1MAPTCASP1CASP7 | |
| SCHEMBL4698038 | 0.79 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL4698044 | 0.79 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL4698043 | 0.79 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL3364072 | 0.78 | GRM2 (0.40) | ALDH1A1MAPT | |
| SCHEMBL3364083 | 0.78 | GRM2 (0.40) | ALDH1A1MAPT | |
| SCHEMBL3364077 | 0.78 | GRM2 (0.40) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| US-7214699-B2 | Indazole derivatives as CRF antagonists | ROCHE PALO ALTO LLC (US) | 2007-05-08 | — | — | US | disclosed |