Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 17/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698038 | 1.00 | CRHR1 (0.34) | CRHR1PDE2APDE4B | |
| SCHEMBL4698044 | 1.00 | CRHR1 (0.34) | CRHR1PDE2APDE4B | |
| Trifluoroacetic Acid SCHEMBL4697870 | 0.92 | CRHR1 (0.33) | CRHR1PDE2APDE4B | |
| Trifluoroacetic Acid SCHEMBL4697872 | 0.92 | CRHR1 (0.33) | CRHR1PDE2APDE4B | |
| SCHEMBL4697443 | 0.79 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL4697442 | 0.79 | CRHR1 (0.42) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4698414 | 0.78 | CRHR1 (0.42) | CRHR1 | |
| Hydrochloric Acid SCHEMBL4698416 | 0.78 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL14409410 | 0.78 | KDM4E (0.37) | — | |
| SCHEMBL3363713 | 0.75 | CRHR1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569911-B1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-02 | — | — | EP | claimed |
| EP-1569911-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004050634-A1 | INDAZOLE DERIVATIVES AS CRF ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-17 | — | — | WO | disclosed |