Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FEN1 | P39748 | 1/20 | 0.30 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | SRC | P12931 | 1/20 | 0.30 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.30 |
| ▸ | TEK | Q02763 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697521 | 0.90 | LMNA (0.39) | BRD4CREBBPLMNA | |
| SCHEMBL4695913 | 0.89 | LMNA (0.38) | BRD4CREBBPLMNA | |
| SCHEMBL4692890 | 0.81 | BRD4 (0.34) | BRD4CREBBPDGAT1ALOX5APFEN1 | |
| SCHEMBL4064723 | 0.76 | PTGS2 (0.50) | DGAT1LMNA | |
| SCHEMBL4503988 | 0.75 | NPSR1 (0.33) | DGAT1NPY5RLMNASMN1; SMN2 | |
| SCHEMBL4696533 | 0.74 | NPC1 (0.34) | NPY5RLMNASMN1; SMN2 | |
| SCHEMBL4697520 | 0.74 | MAPK1 (0.39) | BRD4CREBBPLMNASMN1; SMN2 | |
| SCHEMBL4695367 | 0.74 | MAPK1 (0.39) | BRD4CREBBPLMNASMN1; SMN2 | |
| SCHEMBL4693175 | 0.74 | NPC1 (0.33) | — | |
| SCHEMBL5225574 | 0.71 | NPC1 (0.37) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509528-B1 | 1,3-DIAZA-DIBENZOAZULENES AS INHIBITORS OF TUMOUR NECROSIS FACTOR PRODUCTION AND INTERMEDIATES FOR THE PREPARATION THEREOF | GLAXOSMITHKLINE ZAGREB (HR) | 2008-09-24 | — | — | EP | disclosed |