Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.48 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.48 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3053665 | 0.85 | CSNK1E (0.43) | MAPK14CSNK1ECSNK1DMAPK13MAPK12 | |
| SCHEMBL3054100 | 0.77 | CCNA2 (0.47) | MAPK14CSNK1ECSNK1DMAPK13MAPK12 | |
| SCHEMBL3064617 | 0.74 | MAPK14 (0.57) | MAPK14CSNK1ECSNK1DADORA1 | |
| SCHEMBL3061862 | 0.73 | MAP4K4 (0.48) | MAPK14CSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL5818242 | 0.71 | MAPK14 (0.47) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL3058426 | 0.71 | LMNA (0.40) | MAPK14CSNK1ECSNK1DMAPK13MAPK12 | |
| SCHEMBL3573674 | 0.70 | LMNA (0.50) | MAPK14CSNK1ECSNK1DMAPK13MAPK12 | |
| SCHEMBL5815955 | 0.70 | TGFBR1 (0.56) | MAPK14CSNK1EMAPK13MAPK12MAPK11 | |
| SCHEMBL3075502 | 0.68 | CCNA2 (0.38) | MAPK14CSNK1ECSNK1DMAPK13MAPK12 | |
| SCHEMBL5813444 | 0.67 | KDM4E (0.42) | MAPK14CSNK1EMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922313-A1 | PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS | Laboratorios Almirall, S.A. (ES) | 2008-05-21 | — | — | EP | disclosed |
| WO-2007017096-A1 | PYRAZINE DERIVATIVES USEFUL AS ADENOSINE RECEPTOR ANTAGONISTS | LABORATORIOS ALMIRALL, S.A. (ES) | 2007-02-15 | — | — | WO | disclosed |