Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419583 | 0.85 | ALDH1A1 (0.58) | DRD2MAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL29268404 | 0.84 | NPC1 (0.49) | DRD2NAMPTPARP1LMNATDP1 | |
| SCHEMBL4700826 | 0.84 | PARP1 (0.50) | DRD2NAMPTPARP1TDP1MCL1 | |
| SCHEMBL3510744 | 0.84 | ALDH1A1 (0.50) | MAPTTP53LMNASMN1; SMN2CTDSP1 | |
| SCHEMBL29067082 | 0.83 | EPHX2 (0.59) | DRD2NAMPTLMNAALDH1A1POLB | |
| SCHEMBL22405617 | 0.82 | ALDH1A1 (0.60) | MAPTTP53LMNASMN1; SMN2NPC1 | |
| SCHEMBL22405450 | 0.81 | MAPT (0.47) | MAPTTP53LMNASMN1; SMN2NPC1 | |
| SCHEMBL22405571 | 0.80 | LMNA (0.51) | MAPTTP53LMNASMN1; SMN2TDP1 | |
| SCHEMBL34473423 | 0.80 | LMNA (0.51) | MAPTTP53LMNASMN1; SMN2TDP1 | |
| SCHEMBL34472552 | 0.80 | ALDH1A1 (0.58) | MAPTTP53LMNASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987037-A2 | FUSED HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007097470-A2 | FUSED NITROGEN- COMPRISING HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-08-30 | — | — | WO | disclosed |