Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696420 | 0.76 | NTRK1 (0.51) | NTRK1MKNK1MKNK2IGF1R | |
| SCHEMBL2566466 | 0.75 | NTRK1 (0.48) | NTRK1MKNK1MKNK2IGF1RNUAK1 | |
| SCHEMBL2569963 | 0.75 | NTRK1 (0.48) | NTRK1MKNK1MKNK2MAPK1IGF1R | |
| SCHEMBL3137650 | 0.72 | HTT (0.48) | NTRK1MKNK1MKNK2MAPK1SMN1; SMN2 | |
| SCHEMBL4097106 | 0.72 | MAOB (0.39) | NTRK1MAPK1HDAC1HDAC2MAP2K4 | |
| SCHEMBL4696504 | 0.69 | CYP1A2 (0.49) | NTRK1MKNK1MKNK2MAPK1SMN1; SMN2 | |
| SCHEMBL2207390 | 0.69 | NTRK1 (0.44) | NTRK1MKNK1MKNK2IGF1RNUAK1 | |
| SCHEMBL19806143 | 0.68 | MKNK1 (0.82) | MKNK1MKNK2DRD2DRD4DRD3 | |
| SCHEMBL17749207 | 0.68 | KCNQ3 (0.56) | MAPK1SMN1; SMN2KCNQ3KCNQ2 | |
| SCHEMBL2577693 | 0.68 | PRKCQ (0.44) | NTRK1MKNK1MKNK2IGF1RNUAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853588-B1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-06-18 | — | — | EP | disclosed |