Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17067861 | 1.00 | RIPK1 (0.46) | RIPK1GPR119ALDH1A1LMNANPSR1 | |
| SCHEMBL2695225 | 0.83 | RIPK1 (0.50) | RIPK1ALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL933084 | 0.83 | RIPK1 (0.50) | RIPK1ALDH1A1LMNANPSR1NPC1 | |
| SCHEMBL455372 | 0.83 | AR (0.39) | RIPK1GPR119 | |
| SCHEMBL12477574 | 0.83 | AR (0.39) | RIPK1GPR119 | |
| SCHEMBL456382 | 0.83 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL469718 | 0.83 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL430865 | 0.82 | AR (0.40) | RIPK1GPR119 | |
| SCHEMBL457104 | 0.82 | AR (0.40) | RIPK1GPR119 | |
| SCHEMBL12688003 | 0.82 | AR (0.40) | RIPK1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012116217-A1 | COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-08-30 | — | — | WO | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |